Description Arthrotec is a medication that combines diclofenac (a nonsteroidal anti-inflammatory drug or NSAID) with misoprostol. Description: Arthrotec contains a combination of diclofenac and misoprostol. Diclofenac reduces substances in the body that cause pain and inflammation. Misoprostol protects the lining of the esophagus, stomach, and intestines while taking diclofenac. It is supplied as delayed-release tablets containing either: 75mg diclofenac sodium and 200 mcg misoprostol, or Indication: Arthrotec is indicated for the treatment of the signs and symptoms of osteoarthritis or rheumatoid arthritis in patients at high risk for NSAID-induced gastric or duodenal ulcers. Dosage: For the treatment of rheumatoid arthritis, the recommended dosage of Arthrotec 75 is one tablet twice a day. Side Effects: Common side effects may include abdominal pain, diarrhea, nausea, and headache. Serious side effects include gastrointestinal bleeding, heart attack, stroke, and allergic reactions. Precautions: Do not use Arthrotec if you are pregnant. You must have a negative pregnancy test within 2 weeks before starting Arthrotec. Use effective birth control while using Arthrotec. Avoid Arthrotec if you have active bleeding in your stomach or intestines. Inform your doctor about your medical history, including heart disease, high blood pressure, high cholesterol, diabetes, asthma, liver or kidney disease, and fluid retention. Diclofenac can increase the risk of fatal heart attack or stroke, even without risk factors.
